NCAA Tournament 2022 odds, Final Four picks, March Madness predictions: Model eyeing over in Kansas-Villanova

For an NCAA Tournament that has featured several major upsets, the 2022 March Madness Final Four includes four of the sport’s winningest programs over the past decade. Saturday’s 2022 NCAA Tournament Final Four schedule begins with a matchup between top-seeded Kansas and No. 2 seed Villanova at 6:09 p.m. ET at the Caesars Superdome. The Jayhawks are 4.5-point favorites in the latest 2022 Final Four odds from Caesars Sportsbook, while the total is 133. Kansas recovered from a slow start against No. 10 seed Miami in the Elite Eight, eventually running away from the Hurricanes in a 76-50 final.

Saturday’s nightcap pits No. 2 seed Duke (-4.5) against No. 8 seed North Carolina. It will be the first ever meeting between the Blue Devils and Tar Heels in the NCAA Tournament bracket. All of the 2022 NCAA Tournament lines for the 2022 March Madness Final Four are listed below, and SportsLine’s advanced computer model has all the college basketball betting advice and predictions you need to make the best Final Four picks now.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

The model absolutely crushed its March Madness picks last tournament, beating over 92 percent of all CBS Sports brackets for the second time in three years. The model also nailed a whopping three teams in the Final Four last year. 

Now, it has turned its attention to the latest 2022 NCAA Tournament odds and locked in picks for every Final Four matchup. Head to SportsLine now to see every pick.

Top 2022 NCAA Tournament Final Four predictions

One of the model’s strongest Final Four picks is that the over hits in Kansas vs. Villanova. Kansas wants to turn…


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